SAM-e is a naturally occurring molecule found in almost all tissues. It plays an essential role in the production and activation of proteins, hormones and neurotransmitters. SAM-e administration is associated with increased CNS serotonine, dopamine and norepinephrine levels. It appears to have analgesic and anti-inflammatory properties and seems to stimulate cartilage growth and repair. Oral SAM-e is weakly absorbed. Peak levels are reached 3 to 5 hours after ingestion of an enteric-coated tablet.
Between 400 and 1600 mg daily in 2 or 3 doses.
Loading dose of 600 to 1200 mg daily (in 3 doses) for 2 to 3 weeks followed by 200 mg twice daily.
Usual doses: 800 mg twice daily
There is insufficient reliable information to conclude that SAM-e is effective in any other indication.
In 2004, Canada adopted new regulations that control the manufacturing, packaging, labeling and importing of natural health products. The new regulations also include an adverse reaction reporting system. Products that conform to the regulation's criteria are identified with a natural product number (NPN) and can be legally sold in Canada. This number indicates that the product meets specific criteria for safety and purity, not that it is effective for any indication.
Medicinal plant contents vary naturally from plant to plant - just as fruits from the same package may vary in taste and texture. There is no standard to measure the active content of each plant. Thus, efficacy of natural products should be expected to vary from brand to brand as well as from bottle to bottle of the same brand.
For more information about the Natural Health Products Regulations, or to check if a product has been assessed, visit the Health Canada website at www.hc-sc.gc.ca/dhp-mps/prodnatur/index-eng.php.
© Copyright Vigilance Santé
The patient information leaflets are provided by Vigilance Santé Inc. This content is for information purposes only and does not in any manner whatsoever replace the opinion or advice of your health care professional. Always consult a health care professional before making a decision about your medication or treatment.